Abstract #1872

Multi-Parametric Relationships in Subjects with Liver Iron Overload Obtained using STEAM-MRS at 1.5T and 3T

Gregory Simchick^1,2, Ruiyang Zhao^1,2, Gavin Hamilton³, Scott Reeder^1,2,4,5,6, and Diego Hernando^1,2,4

¹Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Radiology, University of California-San Diego, San Diego, CA, United States, ⁴Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

The relationships between several promising MR biomarkers of diffuse liver disease were evaluated at both 1.5T and 3T in subjects with liver iron overload using stimulated echo acquisition mode (STEAM) MRS. Multi-TE and multi-TE-TR sequences were acquired in order to obtain estimates of R1, R2, FWHM, and PDFF. Linear regression analysis was performed to evaluate the relationships between these various parameters and their relationships across field strengths. Several biomarkers demonstrated moderate to high correlations with each other, and the multi-TE-TR sequence (lower spectral resolution and higher number of spectra than the multi-TE sequence) tended to produce better correlations.

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