In this study, we aimed to investigate the feasibility of quantitative R2* mapping measured using multi-echo ultra-short echo time (multi-TE UTE) MRI for evaluating liver iron content coexisting with liver fat. Iron accumulation and fat deposition with different levels was built in rabbit liver in vivo. We found that the obtained R2* mapping measured with multi-TE UTE with fat suppression could accurate measure liver iron content at different levels without an influence from fat. With this finding, multi-TE UTE imaging can be considered a potential technique for noninvasive hepatic iron measurement.
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