Abstract #1878

Feasibility of T1 Mapping with Histogram Analysis for the Diagnosis and Staging of Liver Fibrosis: Preclinical Results

Qing Wang¹, Ye Sheng², HaiFeng Liu², Zuhui Zhu², wei Xing², and Jilei Zhang³

¹Radiology, Third Affiliated Hospital of Soochow University & First People's Hospital of Changzhou, changzhou, China, ²Third Affiliated Hospital of Soochow University & First People's Hospital of Changzhou, changzhou, China, ³Healthcare,Shanghai,China, shanghai, China

We induced LF New Zealand white rabbits model by carbon tetrachloride to compare the diagnostic accuracy of parameters derived from the histogram analysis of precontrast, 10-min hepatobiliary phase (HBP) and 20-min HBP MOLLI T1 maps for staging liver fibrosis (LF). The mean, median, skewness, kurtosis, entropy, inhomogeneity and 10th/25th/75th/90th percentiles of T1_native, T1_10min and T1_20min were compared. The 75th of T1_native, entropy_10min, and entropy_20min were the three most reliable imaging markers in reflecting the stage of LF. The entropy derived from 20-min HBP T1 mapping is the best parameter for predicting the LF stage.

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