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Abstract #1879

Intenso MRE: 3D volumetric GRE-based MR Elastography of the liver in a single breath-hold

Omar Isam Darwish1,2,3, Sami Jeljeli1, Daniel Staeb4, Peter Speier5, Ralph Sinkus1,2, and Radhouene Neji1,3
1King's College London, London, United Kingdom, 2INSERM U1148, LVTS, University Paris Diderot, Paris, France, 3MR Research Collaborations, Siemens Healthcare Limited, Frimley, United Kingdom, 4MR Research Collaborations, Siemens Healthcare Limited, Melbourne, Australia, 5MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

The increasing use of MR elastography (MRE) for the quantification of liver fibrosis and inflammation demands a rapid and accurate 3D MRE sequence. 3D MRE usually requires multiple breath-holds, which prolongs acquisition times and introduces misalignment between the different acquisitions. We propose Intenso, a novel GRE-MRE sequence that enables 3D motion-encoding for volumetric MRE of the liver in a single breath-hold. The sequence combines simultaneous multi-slice excitation (SMS), Hadamard motion encoding and a multi-shot GRE-MRE sequence resulting in a total acquisition time of 17 seconds. In-vivo results are shown in three healthy volunteers and compared to a well-established GRE-MRE sequence.

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