Abstract #1880

Longitudinal MRI and MR Elastography (MRE) Assessment in Patients with Diagnosed Nonalcoholic Fatty Liver Disease (NAFLD)

Zheng Zhu¹, Alina M. Allen², Terry Therneau³, Xin Lu¹, Kevin J. Glaser¹, Jiahui Li¹, Jingbiao Chen^1,4, Jie Chen^1,5, Safa Hoodeshenas¹, Sudhakar K. Venkatesh¹, Armando Manduca^1,6, Richard L. Ehman¹, and Meng Yin¹

¹Department of Radiology, Mayo Clinic, Rochester, MN, United States, ²Devision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States, ³Devision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States, ⁴Department of Radiology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangdong, China, ⁵Department of Radiology, West China Hospital, Chengdu, Sichuan, China, ⁶Devision of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States

To identify individuals at high risk for rapid fibrosis progression, we retrospectively investigated longitudinal changes in liver stiffness measurements (LSM) and proton density fat fraction (PDFF) in 36 NAFLD patients. At the early fibrosis stages, the rate of change of LSM is slow and positively correlated with the rate of change in PDFF. At later fibrosis stages, the rate of change in LSM is higher and is negatively correlated with ΔPDFF. Compared with other risk factors, the baseline value of LSM and the rate of change in PDFF was most strongly correlated with subsequent change in LSM.

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