Fatigue is a prevalent and debilitating symptom in Inflammatory Bowel Disease (IBD) with an unclear aetiology. Sarcopenia and muscle deconditioning are common in IBD, implicating peripheral mechanisms in IBD fatigue. We carried out functional, 31P MRS and MRI phenotyping of quiescent IBD patients with fatigue complaints and a healthy control group, to characterise peripheral contributions to fatigue aetiology. Collectively, the reduced rate of PCr resynthesis and concomitant maintenance of muscle mass and strength in IBD patients suggests that IBD fatigue may be attributable to peripheral muscle deconditioning, which could potentially be restored by exercise training intervention.
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