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Abstract #1894

31P MRS and MRI phenotyping of muscle metabolic quality in Inflammatory Bowel Disease fatigue

Jordan J McGing1,2,3, Rosemary Nicholas2, S├ębastien Serres4, Paul L Greenhaff5,6,7, Gordon W Moran1,7, and Susan T Francis2
1Nottingham Digestive Diseases Centre, Queens Medical Centre, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, Nottingham, United Kingdom, 3School of Medicine, University of Nottingham, Nottingham, United Kingdom, 4School of Life Sciences, University of Nottingham, Nottingham, United Kingdom, 5MRC Versus Arthritis Centre for Musculoskeletal Ageing Research, Nottingham, United Kingdom, 6Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis, Nottingham, United Kingdom, 7National Institute of Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham, United Kingdom

Fatigue is a prevalent and debilitating symptom in Inflammatory Bowel Disease (IBD) with an unclear aetiology. Sarcopenia and muscle deconditioning are common in IBD, implicating peripheral mechanisms in IBD fatigue. We carried out functional, 31P MRS and MRI phenotyping of quiescent IBD patients with fatigue complaints and a healthy control group, to characterise peripheral contributions to fatigue aetiology. Collectively, the reduced rate of PCr resynthesis and concomitant maintenance of muscle mass and strength in IBD patients suggests that IBD fatigue may be attributable to peripheral muscle deconditioning, which could potentially be restored by exercise training intervention.

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