Abstract #1893

Inter-hemispheric Functional Connections are more Vulnerable to Attack than Structural Connection in Irritable Bowel Syndrome Patients

Guangyao Liu¹, Shan Li², Hong Liu¹, Laiyan Ma¹, Zhijun Yao², Jing Zhang¹, Shaoyu Wang³, and Dekui Zhang⁴

¹Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China., Lanzhou, China, ²Gansu Provincial Key Laboratory of Wearable Computing, School of Information Science and Engineering, Lanzhou University, Lanzhou, China., Lanzhou, China, ³MR Scientific Marketing, Siemens Healthineers, Shanghai, China., xian, China, ⁴Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, China., Lanzhou, China

In this study, five types of MRI features, including voxel-mirrored homotopic connectivity (VMHC) from functional MRI (fMRI), asymmetry index (AI) from structural MRI (sMRI), FA, fiber length and fiber number (FN) from diffusion tensor imaging (DTI) were used to evaluate the asymmetry and inter-hemispheric connectivity of IBS patients. Through taking comprehensive analysis of the bilateral brain in Irritable bowel syndrome (IBS) patients, we speculated that inter-hemispheric functional connectivity is more vulnerable to IBS than anatomical connectivity, while the structural morphology of brain is the most stable. Meanwhile, the affected areas were concentrated in default mode network (DMN) and sensorimotor network. The results of our study are only preliminary, but it may provide theoretical basis for future research on the regulation of gut-brain axis (GBA) and pathophysiology in functional intestinal diseases.

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