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Abstract #1907

Frequency-dependent changes in the spontaneous neural activity are associated with cognitive impairment in patients with presbycusis

fei gao1, fuxin ren1, weibo chen2, and muwei li3
1Shandong Medical Imaging Research Institute, Shandong University, jinan, China, 2Philips Healthcare, shanghai, China, 3Vanderbilt University Institute of Imaging Science, Nashville, TN, United States

Previous studies have linked Presbycusis (PC) to cognitive impairment and incident Alzheimer’s disease. However, the neural mechanisms of cognitive impairment in patients with PC remain unclear. Although resting-state functional MRI studies have explored low-frequency oscillation (LFO) connectivity or amplitude of PC-related neural activity, it remains unclear whether the abnormalities occur within all frequency bands or within specific frequency bands. Therefore, we applied ALFF to examine changes in LFO amplitudes in PC patients at different frequency bands (slow-4 and slow-5). Then, we used brain regions showing altered ALFF as seeds to explore FC between these regions and all other brain voxels.

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