Abstract #1908

Myelin Water Fraction Imaging in Patients with Alzheimer's Disease and Mild Cognitive Impairment

Geon-Ho Jahng^1,2, Ji Yoon Lee³, Seung-Hyun Lim¹, Hak Young Rhee⁴, Soonchan Park^1,2, Jongho Lee⁵, and Chang-Woo Ryu^1,2

¹Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ²Medicine, Kyung Hee University, Seoul, Korea, Republic of, ³Biomedical Engineering, Kyung Hee University, Yongin-si, Korea, Republic of, ⁴Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ⁵Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of

The objective of this study was to investigate myelin loss in participants with AD, MCI, and cognitively normal (CN) elderly using the whole brain MWF map. The ViSTa-GRASE sequence provides the good MWF map in a reasonable scan time to evaluate myelin loss in AD patients. MWF was significantly reduced in AD compared with CN, indicating the presence of widespread demyelination in AD. In addition, MWF was significantly correlated with memory decline, indicating that MWF could serve as a potential imaging biomarker for AD for evaluating demyelination and predicting treatment outcomes.

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