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Abstract #1912

Alterations and associations between magnetic susceptibility of the basal ganglia and diffusion properties in Alzheimer's disease

Xiuxiu Liu1, Lei Du1,2, Wenwen Gao1, Bing Liu1,2, Yue Chen1, Yige Wang1,2, Guolin Ma1, and Weiyin Liu3
1Department of Radiology, China-Japan Friendship Hospital, Beijing, China, 2Graduate School of Peking Union Medical College, Beijing, China, 3GE Healthcare, Beijing, China

Whether excessive iron deposition in basal ganglia of Alzheimer’s patients can affect the diffusion function of white matter is still unknown. There were 30 Alzheimer’s patients and 19 healthy controls in this study. We used diffusion tensor imaging and quantitative susceptibility mapping to discover the alterations of diffusion function and magnetic susceptibility of brain and associations between diffusion indexes, magnetic susceptibility, and cognitive function. This study revealed that diffusion indexes and magnetic susceptibility changed which were related to cognitive impairment. In addition, increasing magnetic susceptibility due to iron deposition may adversely affect the diffusion function of brain.

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