Diseases with age as the primary risk factor increase in prevalence as life expectancy increases. Aging is implicated in cardiovascular (CV) disease and neurodegeneration. As the stiffness of the proximal aorta increases, damaging pulses of pressure have been postulated to propagate into the brain. The purpose of this study was to relate vascular and brain pathology through non-invasive measures in normal and hypertensive rodents. Brain pathology was detected by multiple MRI contrast mechanisms, while specific vascular parameters were derived from ultrasound in the aorta. Non-invasive measures relating brain and vascular aging could aid in the future development of therapeutic strategies.
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