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Abstract #1915

Hippocampal viscoelasticity is associated with risk of mild cognitive impairment

Lucy V Hiscox1, Emma M Tinney1, Peyton L Delgorio1, Matthew DJ McGarry2, Alyssa Lanzi3, James M Ellison4, Matthew L Cohen3, Chris R Martens5, and Curtis L Johnson1
1Department of Biomedical Engineering, University of Delaware, Newark, DE, United States, 2Dartmouth College, Hanover, NH, United States, 3Department of Communication Sciences & Disorders, University of Delaware, Newark, DE, United States, 4Swank Center for Memory Care and Geriatric Consultation, ChristianaCare, Wilmington, DE, United States, 5Kinesiology and Applied Physiology, University of Delaware, Newark, DE, United States

The health and integrity of the hippocampus is implicated in the development of mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Neuroimaging techniques evaluate the characteristics of hippocampal health in vivo, including its size, diffusion properties, and blood flow. In this study, we show that the mechanical properties of the hippocampus, obtained through magnetic resonance elastography (MRE), are associated with an increased risk of MCI, when other techniques are not. Establishing risk based on practically relevant quantitative changes in neuroimaging variables can help identify participants likely to develop cognitive impairment and assist in establishing the effectiveness of treatment interventions.

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