Abstract #1915

Hippocampal viscoelasticity is associated with risk of mild cognitive impairment

Lucy V Hiscox¹, Emma M Tinney¹, Peyton L Delgorio¹, Matthew DJ McGarry², Alyssa Lanzi³, James M Ellison⁴, Matthew L Cohen³, Chris R Martens⁵, and Curtis L Johnson¹

¹Department of Biomedical Engineering, University of Delaware, Newark, DE, United States, ²Dartmouth College, Hanover, NH, United States, ³Department of Communication Sciences & Disorders, University of Delaware, Newark, DE, United States, ⁴Swank Center for Memory Care and Geriatric Consultation, ChristianaCare, Wilmington, DE, United States, ⁵Kinesiology and Applied Physiology, University of Delaware, Newark, DE, United States

The health and integrity of the hippocampus is implicated in the development of mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Neuroimaging techniques evaluate the characteristics of hippocampal health in vivo, including its size, diffusion properties, and blood flow. In this study, we show that the mechanical properties of the hippocampus, obtained through magnetic resonance elastography (MRE), are associated with an increased risk of MCI, when other techniques are not. Establishing risk based on practically relevant quantitative changes in neuroimaging variables can help identify participants likely to develop cognitive impairment and assist in establishing the effectiveness of treatment interventions.

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