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Abstract #1916

Brain rejuvenation improves accuracy of automatic segmentation of the aged brain

Roman Fleysher1, Mohammad Mansouri1, and Michael L Lipton1
1Radiology, Albert Einstein College of Medicine, Bronx, NY, United States

Despite best efforts, performance of automatic brain segmentation is inferior in older adults. We hypothesize that worsening of segmentation quality with age is related to brain atrophy and changes to image contrast. To disentangle the two possibilities, we simulated brain atrophy and confirmed worse segmentation performance. We then propose and demonstrate “brain rejuvenation” as a method to improve segmentation of the aged brain.

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