Meeting Banner
Abstract #1917

Neurite dispersion and density across the adult lifespan investigated using a modified NODDI approach

Maryam H. Alsameen1, Wenshu Qian1, Matthew Kiely1, Curtis Triebswetter1, Zhaoyuan Gong1, and Mustapha Bouhrara1
1National Institute on Aging, NIH, Baltimore, MD, United States

The NODDI approach has been shown to overestimate the CSF and neurite density (NDI) fractions in white matter. We propose a new modification to the NODDI algorithm to address these issues. Our approach requires minimal extension of the total acquisition time. While the neurite orientation dispersion (ODI) values were consistent between the two approaches, the modified NODDI approach provides lower, more physiologically plausible, NDI values as compared to those derived using the original NODDI approach. Further, NDI and ODI exhibit, overall, quadratic associations with age. These associations were more pronounced and significant from results derived using the modified NODDI approach.

This abstract and the presentation materials are available to members only; a login is required.

Join Here