The NODDI approach has been shown to overestimate the CSF and neurite density (NDI) fractions in white matter. We propose a new modification to the NODDI algorithm to address these issues. Our approach requires minimal extension of the total acquisition time. While the neurite orientation dispersion (ODI) values were consistent between the two approaches, the modified NODDI approach provides lower, more physiologically plausible, NDI values as compared to those derived using the original NODDI approach. Further, NDI and ODI exhibit, overall, quadratic associations with age. These associations were more pronounced and significant from results derived using the modified NODDI approach.
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