Little is known about the role of APOE isoforms in cerebral myelination. Although several quantitative MRI studies have demonstrated the influence of APOE on cerebral tissue integrity, its specific implication in brain myelination remains to be established. In this work, we investigated associations between APOE isoforms ε2 or ε4 and myelination, probed using specific and nonspecific measures of myelin content, in multiple brain regions in a cohort of cognitively unimpaired participants spanning a wide age range. We show significant correlations between APOE isoforms ε2 or ε4 and myelin content in several brain structures.
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