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Abstract #1919

A neuroimaging study of the effects of early versus late anti-inflammatory treatment in the TgF344-AD rat model of Alzheimer’s disease

Caitlin F Fowler1,2, Dan Madularu3, Gabriel A Devenyi4,5, John Breitner5,6, and Jamie Near1,4,5
1Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada, 2Cerebral Imaging Centre, Douglas Hospital Research Centre, Verdun, QC, Canada, 3Center for Translational Neuroimaging, Northeastern University, Boston, MA, United States, 4Cerebral Imaging Centre, Douglas Hospital Research Institute, Verdun, QC, Canada, 5Psychiatry, McGill University, Montreal, QC, Canada, 6Division of Human Neurosciences, Douglas Hospital Research Centre, Verdun, QC, Canada

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with no effective treatments or known biomarkers for definitive diagnosis, substantiating the need for early detection and intervention. This project employs Magnetic Resonance Spectroscopy to quantify neurochemical changes in the TgF344-AD rat model of AD in response to early versus late administration of a common non-steroidal anti-inflammatory drug, specifically addressing the critical question of treatment timing. Preliminary results suggest the TgF344-AD rat recapitulates most neurochemical features of human AD and that early treatment is more effective than late treatment at mitigating disease-related neurochemical changes.

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