Abstract #1919

A neuroimaging study of the effects of early versus late anti-inflammatory treatment in the TgF344-AD rat model of Alzheimer’s disease

Caitlin F Fowler^1,2, Dan Madularu³, Gabriel A Devenyi^4,5, John Breitner^5,6, and Jamie Near^1,4,5

¹Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada, ²Cerebral Imaging Centre, Douglas Hospital Research Centre, Verdun, QC, Canada, ³Center for Translational Neuroimaging, Northeastern University, Boston, MA, United States, ⁴Cerebral Imaging Centre, Douglas Hospital Research Institute, Verdun, QC, Canada, ⁵Psychiatry, McGill University, Montreal, QC, Canada, ⁶Division of Human Neurosciences, Douglas Hospital Research Centre, Verdun, QC, Canada

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with no effective treatments or known biomarkers for definitive diagnosis, substantiating the need for early detection and intervention. This project employs Magnetic Resonance Spectroscopy to quantify neurochemical changes in the TgF344-AD rat model of AD in response to early versus late administration of a common non-steroidal anti-inflammatory drug, specifically addressing the critical question of treatment timing. Preliminary results suggest the TgF344-AD rat recapitulates most neurochemical features of human AD and that early treatment is more effective than late treatment at mitigating disease-related neurochemical changes.

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