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Abstract #1923

The DKI value in detecting microstructural white matter alterations in Alzheimer's disease and amnestic mild cognitive impairment: A TBSS study

Tongtong Li1, Yu Zhang1, Xiuwei Fu2, Xianchang Zhang3, Yuan Luo4, and Hongyan Ni5
1First Central Clinical College, Tianjin Medical University, Tianjin, China, 2Tianjin Medical University General Hospital, Tianjin, China, 3MR Collaboration, Siemens Healthcare Ltd, Beijing, China, 4Department of Radiology, China-Japan Friendship Hospital, Beijing, China, 5Department of Radiology, Tianjin First Central Hospital, Tianjin, China

Previous studies that used diffusion kurtosis imaging to study Alzheimer's disease (AD) mostly analyzed data based on regions of interest method, which may be biased by subjectivity. This study used Tract-based Spatial Statistics (TBSS) method to analyze the DKI data and found that kurtosis fractional anisotropy (KFA) values outperformed other DKI-derived parameters in sensitive detection of microstructural white matter damage for early diagnosis of amnestic mild cognitive impairment (aMCI) and AD.

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