Abstract #1923

The DKI value in detecting microstructural white matter alterations in Alzheimer's disease and amnestic mild cognitive impairment: A TBSS study

Tongtong Li¹, Yu Zhang¹, Xiuwei Fu², Xianchang Zhang³, Yuan Luo⁴, and Hongyan Ni⁵

¹First Central Clinical College, Tianjin Medical University, Tianjin, China, ²Tianjin Medical University General Hospital, Tianjin, China, ³MR Collaboration, Siemens Healthcare Ltd, Beijing, China, ⁴Department of Radiology, China-Japan Friendship Hospital, Beijing, China, ⁵Department of Radiology, Tianjin First Central Hospital, Tianjin, China

Previous studies that used diffusion kurtosis imaging to study Alzheimer's disease (AD) mostly analyzed data based on regions of interest method, which may be biased by subjectivity. This study used Tract-based Spatial Statistics (TBSS) method to analyze the DKI data and found that kurtosis fractional anisotropy (KFA) values outperformed other DKI-derived parameters in sensitive detection of microstructural white matter damage for early diagnosis of amnestic mild cognitive impairment (aMCI) and AD.

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