Abstract #1924

Multimodal MR imaging reveals distinct sensitivity of hippocampal subfields to normal aging and asymptomatic Alzheimer's disease pathology

Junjie Wu¹, Syed S. Shahid^2,3, Qixiang Lin², Antoine Hone-Blanchet², Jeremy L. Smith¹, Benjamin B. Risk⁴, Aditya S. Bisht², David W. Loring², Felicia C. Goldstein², Allan I. Levey², Bruce A. Crosson^2,5, James J. Lah², and Deqiang Qiu^1,6

¹Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, ²Department of Neurology, Emory University School of Medicine, Atlanta, GA, United States, ³Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ⁴Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA, United States, ⁵Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, Decatur, GA, United States, ⁶Joint Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States

Using structural, resting-state functional and diffusion MRI, we report that normal aging affects functional connectivity and tissue microstructure in all hippocampal subfields, while the subiculum and CA1-3 exhibit the greatest sensitivity to asymptomatic Alzheimer’s disease pathology with CA1-3 hyperconnectivity. The imaging measures correlate with neuropsychological performance and CSF tau.

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