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Abstract #1931

Impact of Dementia with Lewy Bodies on Brain Biomechanical Properties

KowsalyaDevi Pavuluri1, John Huston III1, Richard L. Ehman1, Armando Manduca1,2, Clifford R. Jack Jr1, Rodolfo Savica3, Bradley F Boeve4, Kejal Kantarci1, David S Knopman3, Ronald C. Petersen3, and Matthew C. Murphy1
1Department of Radiology, Mayo Clinic, Rochester, MN, United States, 2Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, United States, 3Department of Neurology, Mayo Clinic, Rochester, MN, United States, 4Division of Pulmonary and Critical Care Medicine, Mayo Center for Sleep Medicine, Mayo Clinic, Rochester, MN, United States

Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia in older people after Alzheimer’s, accounting for 10-15% of all dementia cases. In this study we used Magnetic Resonance Elastography (MRE) to assess the feasibility of using the changes in brain mechanical properties as potential biomarkers.

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