Abstract #1931

Impact of Dementia with Lewy Bodies on Brain Biomechanical Properties

KowsalyaDevi Pavuluri¹, John Huston III¹, Richard L. Ehman¹, Armando Manduca^1,2, Clifford R. Jack Jr¹, Rodolfo Savica³, Bradley F Boeve⁴, Kejal Kantarci¹, David S Knopman³, Ronald C. Petersen³, and Matthew C. Murphy¹

¹Department of Radiology, Mayo Clinic, Rochester, MN, United States, ²Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, United States, ³Department of Neurology, Mayo Clinic, Rochester, MN, United States, ⁴Division of Pulmonary and Critical Care Medicine, Mayo Center for Sleep Medicine, Mayo Clinic, Rochester, MN, United States

Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia in older people after Alzheimer’s, accounting for 10-15% of all dementia cases. In this study we used Magnetic Resonance Elastography (MRE) to assess the feasibility of using the changes in brain mechanical properties as potential biomarkers.

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