Abstract #1932

Investigation of brain regional relaxation characteristics in healthy subjects during normal aging using synthetic MRI

Di Wang¹, Lu Yu², Pu-Yeh Wu³, Chunmei Li², and Min Chen²

¹Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, P.R. China, Bejing, China, ²Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, P.R. China, Beijing, China, ³GE Healthcare, Beijing, China, Beijing, China

Synthetic MRI is a novel method that simultaneously provides quantitative relaxation mapping and synthetic contrast-weighted images. In this study, we adopted this technique to investigate the age-related relaxation characteristics alterations in healthy subjects by brain region-based regression analysis. Specifically, we found significant differences of relaxation characteristics between left and right hemispheres in the frontal and occipital white matter, and the genu and splenium of corpus callosum. T1, T2 and PD showed a quadratic trend with age. Overall, our findings suggested that the relaxation characteristics provided by the synthetic MRI can be considered an effective tool for detecting brain aging.

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