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Abstract #1933

Altered resting-state network connectivity in patients with presbycusis

fei gao1, fuxin ren1, weibo chen2, and muwei li3
1Shandong Medical Imaging Research Institute, Shandong University, jinan, China, 2Philips Healthcare, shanghai, China, 3Vanderbilt University Institute of Imaging Science, Nashville, TN, United States

Presbycusis (PC) is a gradually progressive bilateral symmetrical sensory-neural hearing loss, characterized by hearing loss at high frequencies. As the most common sensory deficit in older adults, hearing deprivation was proved to be the independent influencing factor of dementia. However, the exact pathophysiological mechanism of PC and its relationship with cognitive impairment is largely unknown. In this study, therefore, we applied an ICA-based resting-state networks (RSNs) analysis to examine changes in functional connectivity of intra- and inter-network in patients with PC. Then, we explore the relationship between these abnormal functional connectivity and cognitive impairments in PC patients.

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