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Abstract #1934

Thalamic nuclei changes in prodromal and clinical Alzheimer’s disease

Adam S Bernstein1, Steve Z Rapcsak2, Michael Hornberger3, and Manojkumar Saranathan4
1College of Medicine, University of Arizona, Tucson, AZ, United States, 2Department of Neurology, University of Arizona, Tucson, AZ, United States, 3Department of Medicine, University of East Anglia, Norwich, United Kingdom, 4Department of Medical Imaging, University of Arizona, Tucson, AZ, United States

Using a novel multi-atlas segmentation technique, we studied the atrophy of thalamic nuclei as a function of disease progression in Alzheimer’s disease. We found statistically significant atrophy of the anteroventral, centromedian, and mediodorsal nuclei, which are part of the limbic system and known to play a known role in memory and cognitive function. We also found atrophy of the medial geniculate nucleus and the pulvinar nucleus. The degree of atrophy increases from early MCI to full AD. These findings suggest that a larger network of brain structures are affected in Alzheimer’s disease, which together lead to the clinical presentation.

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