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Abstract #1938

DGE-MRI detects the therapeutic effect of IL-33 in Alzheimer’s mice by assessing cerebral glucose uptake and clearance at 3T

Zilin Chen1, Jianpan Huang1, Yang Liu1, Joseph H.C. Lai1, and Kannie W.Y. Chan1,2,3
1Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3City University of Hong Kong Shenzhen Research Institute, Shenzhen, China

We have demonstrated that D-glucose kinetics detected by dynamic glucose-enhanced (DGE)-MRI can be used to assess D-glucose uptake and clearance alterations in Alzheimer’s disease (AD) mice at 3T. Interleukin (IL)-33 treatment has been shown to promote Aβ clearance. Here, we applied our established DGE-MRI to detect changes of brain clearance after IL-33 treatment in cerebrospinal fluid (CSF) and brain parenchyma in AD mice. A significant increased D-glucose clearance from CSF, but not brain parenchyma, was observed after treatment. DGE-MRI provides a non-invasive evaluation of IL-33 treatment in AD, and further affirm its potential to assess brain lymphatic system in AD.

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