Abstract #1938

DGE-MRI detects the therapeutic effect of IL-33 in Alzheimer’s mice by assessing cerebral glucose uptake and clearance at 3T

Zilin Chen¹, Jianpan Huang¹, Yang Liu¹, Joseph H.C. Lai¹, and Kannie W.Y. Chan^1,2,3

¹Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong, ²Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³City University of Hong Kong Shenzhen Research Institute, Shenzhen, China

We have demonstrated that D-glucose kinetics detected by dynamic glucose-enhanced (DGE)-MRI can be used to assess D-glucose uptake and clearance alterations in Alzheimer’s disease (AD) mice at 3T. Interleukin (IL)-33 treatment has been shown to promote Aβ clearance. Here, we applied our established DGE-MRI to detect changes of brain clearance after IL-33 treatment in cerebrospinal fluid (CSF) and brain parenchyma in AD mice. A significant increased D-glucose clearance from CSF, but not brain parenchyma, was observed after treatment. DGE-MRI provides a non-invasive evaluation of IL-33 treatment in AD, and further affirm its potential to assess brain lymphatic system in AD.

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