Abstract #1937

Does basal forebrain volume reduction in MRI indicate cholinergic degeneration? A validation study in mouse model of Alzheimer’s Disease

Xiaoqing Alice Zhou¹, Grace Ngiam¹, Lei Qian², Tammy Sankorrakul³, Elizabeth J Coulson², and Kai-Hsiang Chuang⁴

¹QBI/SBMS, The University of Queensland, Brisbane, Australia, ²SBMS/QBI, The University of Queensland, Brisbane, Australia, ³SBMS, The University of Queensland, Brisbane, Australia, ⁴QBI/CAI, The University of Queensland, Brisbane, Australia

3xTg mouse model of AD have smaller basal forebrain volume measured by MRI

MRI-detected volume changes do not correlate with cholinergic neurons

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