Does basal forebrain volume reduction in MRI indicate cholinergic degeneration? A validation study in mouse model of Alzheimer’s Disease
Xiaoqing Alice Zhou1, Grace Ngiam1, Lei Qian2, Tammy Sankorrakul3, Elizabeth J Coulson2, and Kai-Hsiang Chuang4
1QBI/SBMS, The University of Queensland, Brisbane, Australia, 2SBMS/QBI, The University of Queensland, Brisbane, Australia, 3SBMS, The University of Queensland, Brisbane, Australia, 4QBI/CAI, The University of Queensland, Brisbane, Australia
3xTg mouse model of AD have smaller basal forebrain volume measured by MRI
MRI-detected volume changes do not correlate with cholinergic neurons
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