Abstract #1936

Cardiovascular fitness does not influence relationships between cortical thickness and obesity in aging

Brittany Intzandt^1,2,3, Safa Sanami⁴, Julia Huck⁴, Richard D Hoge⁵, Louis Bherer^2,3,6,7, and Claudine J Gauthier^3,4,6

¹INDI Department, Concordia University, Montreal, QC, Canada, ²Centre de Recherche de l'Institut Universitaire de Geriatrie, Montreal, QC, Canada, ³Centre de Recherche, l'Institut de Cardiologie de Montréal, Montreal, QC, Canada, ⁴Physics Department, Concordia University, Montreal, QC, Canada, ⁵Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada, ⁶PERFORM Centre, Concordia Univeristy, Montreal, QC, Canada, ⁷Départment de Médicine, Université de Montréal, Montreal, QC, Canada

Cortical thinning occurs during aging and has been reported to worsen with increased adiposity, although this relationship seems dependent on sex. Increased cortical thickness is related to greater cardiovascular fitness in aging, but previous work has not explored if fitness moderates these conflicting relationships between overweight and cortical thinning. Here, we investigated if fitness moderates relationships between overweight status and cortical thickness in older women and men. Results revealed overweight women had greater cortical thickness than overweight men, but fitness did not moderate this. Future work should investigate sex hormones to further understand these sex differences in overweight individuals.

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