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Abstract #1940

Longitudinal Characterization of Volumetric Changes During Healthy Aging and Between Sexes in the Fischer 344 Rat Brain 

Dana Goerzen1,2, Caitlin Fowler1,2, Dan Madularu3, Gabriel A Devenyi2, M. Mallar Chakravarty1,2, and Jamie Near1,2
1McGill University, Montreal, QC, Canada, 2Centre d'Imagerie Cérébrale, Douglas Mental Health University Institute, Montreal, QC, Canada, 3Center for Translational Neuroimaging, Northeastern University, Boston, MA, United States

In order to design effective interventions for age-related diseases, it is necessary to first understand the biological processes associated with healthy aging. In this way, physiological changes during aging can be distinguished from those arising due to pathology. To this end, we present a comprehensive analysis of MRI-derived volumetric brain changes during healthy aging in a mixed-sex cohort of 27 Fischer 344 wildtype rats. These findings contribute to our understanding of the baseline neuroanatomical changes associated with healthy aging in both sexes, critical for the proper identification and management of age-related diseases, which frequently present in sexually dimorphic ways.

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