Abstract #1940

Longitudinal Characterization of Volumetric Changes During Healthy Aging and Between Sexes in the Fischer 344 Rat Brain

Dana Goerzen^1,2, Caitlin Fowler^1,2, Dan Madularu³, Gabriel A Devenyi², M. Mallar Chakravarty^1,2, and Jamie Near^1,2

¹McGill University, Montreal, QC, Canada, ²Centre d'Imagerie Cérébrale, Douglas Mental Health University Institute, Montreal, QC, Canada, ³Center for Translational Neuroimaging, Northeastern University, Boston, MA, United States

In order to design effective interventions for age-related diseases, it is necessary to first understand the biological processes associated with healthy aging. In this way, physiological changes during aging can be distinguished from those arising due to pathology. To this end, we present a comprehensive analysis of MRI-derived volumetric brain changes during healthy aging in a mixed-sex cohort of 27 Fischer 344 wildtype rats. These findings contribute to our understanding of the baseline neuroanatomical changes associated with healthy aging in both sexes, critical for the proper identification and management of age-related diseases, which frequently present in sexually dimorphic ways.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.