Abstract #1941

Testing the cognitive reserve hypothesis in the non-Western populations: evidence from a multicentric neuroimaging study in India

Brenton James Keller¹, Jorge Jovicich², Himanshu Joshi³, Leon Aksman⁴, John John³, A. B. Dey⁵, Arthur Toga⁴, Eileen Crimmins⁶, and Jinkook Lee¹

¹CSCR, University of Southern California, Los Angeles, CA, United States, ²Center for Mind/Brain Sciences (CIMEC),, University of Trento, Trento, Italy, ³Multimodal Brain Image Analysis Laboratory, National Institute of Mental Health and Neurosciences, Bangalore, India, ⁴Laboratory of Neuro Imaging, University of Southern California, Los Angeles, CA, United States, ⁵All India Institute of Medical Sciences, New Delhi, India, ⁶Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States

Education offers neuroprotective effects against the progression of dementia. Limited information exists about such effects in non-Western populations, where formal education can be critically reduced. Here we examined dementia and education effects on brain morphometry in elderly healthy and mild cognitive impaired Indians. Morphometry revealed atrophy in areas typically related to MCI, enlarged lateral ventricles and reduced hippocampal volume. Education increased cortical thickness atrophy in the parahippocampal and temporal cortices (MCI group). This supports the cognitive reserve hypothesis, in which inter-individual differences in task processing is believed to allow some individuals to better cope with the neuropathology associated with dementia.

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