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Abstract #1994

Mapping of downfield resonances in the human brain using 1H-MRSI with binomial spectral-spatial excitation and selective refocusing

Michal Považan1, Michael Schär1, Joseph S Gillen1,2, and Peter B Barker1,2
1Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Kennedy Krieger Institute, F. M. Kirby Research Center for Functional Brain Imaging, Baltimore, MD, United States

Water suppression employed in 1H-MR spectroscopy affects signals of exchangeable protons that resonate downfield from water. We have developed a novel method without water suppression for mapping these resonances on a 3T scanner using 2D 1H-MRSI in combination with binomial spectral spatial excitation and selective refocusing. Acquired data were consistent across all scanned subjects and within the whole FOV, with spectral patterns in agreement with previous single voxel studies.

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