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Abstract #1993

Detection and quantification of NAD+ in the human brain at 3 T: Comparison of three different localization techniques

Martyna Dziadosz1, Maike Hoefemann1, André Döring2, Malgorzata Marjanska3, Edward Auerbach3, and Roland Kreis1
1Departments of Radiology and Biomedical Research, University of Bern, Bern, Switzerland, 2Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 3Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minnesota, MN, United States

The detection and quantification of Nicotinamide adenine dinucleotide (NAD+) was demonstrated to be challenging in 1H Magnetic Resonance Spectroscopy, due to its low concentration and reported polarization exchange with water. Frequency-selective excitation with slice-selective refocusing was proposed to prevent saturation-transfer from water. In this study we compare three techniques to access NAD+ quantification – standard WS semiLASER and two nWS (MC semiLASER and 2D I-CSE). NAD+ was detected with all techniques with a limited visibility for the WS semiLASER. While utilizing nWS concept allows to detect NAD+ at the visibility of 66%.

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