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Abstract #1992

Improved prospective frequency correction for macromolecule-suppressed GABA editing with metabolite cycling at 3T

Kimberly Chan1, Andreas Hock2, Richard Edden3,4, Erin MacMillan5, and Anke Henning1,6
1The University of Texas Southwestern, Dallas, TX, United States, 2MR Clinical Science, Philips Health Systems, Horgen, Switzerland, 3Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 5UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 6Max Planck Institute for Biological Cybernetics, Tübingen, Germany

Macromolecule-suppressed GABA-editing with symmetrical suppression is often preferred over conventional GABA-editing due to its greater specificity. However, this pulse sequence is more sensitive to magnetic field instabilities than conventional GABA-editing. This leads to macromolecule contamination in the edited GABA signal. Here, we combine metabolite cycling with J-difference (MC-MEGA) editing to allow for prospective volume-localized frequency correction at each repetition time without the acquisition of additional water reference transients. We show here that prospective MC-MEGA reduces B0 field instability relative to intermittent prospective frequency correction with water suppressed (WS) MEGA and reduces macromolecule contamination and subtraction artifacts.

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