The aim of this work was to investigate an alternative MRS approach for GABA editing. By performing a range of simulations, we found a long-TE scheme that reduces the influence of co-edited macromolecular signal without lower GABA losses than long-TE MEGA-PRESS. We termed this scheme ‘Mixed flip angle’ (MFA) editing, and validated the scheme with phantom measurements and a proof-of-principle in vivo measurement. Preliminary results show that longer-TE editing of GABA has the potential to increase selectivity by allowing for longer editing pulse duration, avoiding the need for symmetrical suppression of MM signals.
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