Abstract #1991

Long-TE mixed flip angle editing of GABA

Sofie Tapper^1,2, Muhammad G. Saleh³, Helge J. Zöllner^1,2, Steve C.N. Hui^1,2, and Richard A.E. Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States

The aim of this work was to investigate an alternative MRS approach for GABA editing. By performing a range of simulations, we found a long-TE scheme that reduces the influence of co-edited macromolecular signal without lower GABA losses than long-TE MEGA-PRESS. We termed this scheme ‘Mixed flip angle’ (MFA) editing, and validated the scheme with phantom measurements and a proof-of-principle in vivo measurement. Preliminary results show that longer-TE editing of GABA has the potential to increase selectivity by allowing for longer editing pulse duration, avoiding the need for symmetrical suppression of MM signals.

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