Abstract #1990

SLOW: Whole Brain Spectral Editing EPSI Based Technique using Chemical Selective Adiabatic 2π-Refocusing Pulses applied to 2HG and GABA Editing

Guodong Weng¹, Claus Kiefer¹, Irena Zubak², and Johannes Slotboom¹

¹Institute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland, ²Department of Neurosurgery, Inselspital Bern and University Hospital, Bern, Switzerland

To overcome the B₁⁺ inhomogeneities and SAR limitation for using MRSI-editing at UHT (≥7T), a new spectral editing scheme was developed within an EPSI sequence for whole brain MRSI. The slice-selective refocusing pulse was replaced by a chemical-selective adiabatic 2π-refocusing pulse pair with varying passbands. The results show an excellent glutamate, 2HG and GABA-editing pattern with in vitro and in vivo measurements. This study has shown the excellent performance of the proposed new spectral editing scheme, and proved that it could be an alternative method for MEGA editing.

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