Offsets in B0 field frequency have a detrimental impact on the SNR, linewidth, and editing efficiency of edited 1H MRS data. We have previously described an interleaved water referencing (IWR) method for interspersed acquisition of the unsuppressed water signal to correct frequency drift at regular intervals. Here, we add to IWR a spectral registration (SR) approach for updating the center frequency every TR. Proof-of-concept results from phantom and in vivo experiments demonstrate that SR can be successfully combined with IWR for fully prospective correction of frequency offsets across the whole edited MRS scan.
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