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Abstract #1988

GOIA-WURST optimisation for ultra-high field single-voxel MRS at short-TE

Adam Berrington1, Joseph S Gillen2,3, and Vincent Boer4
1Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, United Kingdom, 3F.M. Kirby Research Centre, Kennedy Krieger Institute, Baltimore, MD, United States, 4Danish Research Centre for Magnetic Resonance,Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark

Gradient modulated pulses allow for accurate slice localisation in single-voxel MRS. However, they suffer from ‘smearing’ artifacts at off-resonance leading to poor performance across the inversion band, particularly when B1 field strength is low. An optimized GOIA-WURST pulse shape was found by simulating changes in the modulation parameters to improve the off-resonance profile at 7T for B1 of 15 μT. When used in a semi-LASER localisation, the optimised GOIA(50,10) pulses resulted in a minimum TE of 23 ms which led to upright peak shapes for J-coupled multiplets in phantom.

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