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Abstract #2012

Data-driven bases optimization for fitting of in vivo MR spectra

Alexander Saunders1,2 and Stefan Bluml1,2
1Radiology, Children's Hospital Los Angeles/USC, Los Angeles, CA, United States, 2Rudi Schulte Research Institute, Santa Barbara, CA, United States

In vivo MR spectra are commonly analyzed by fitting linear combinations of metabolite basis spectra. In this study we explored whether in vivo spectra themselves can provide information that can be used to further optimize basis spectra. Software was developed that includes the capability to modify basis spectra as part of the fitting procedure. The chemical shifts and J-couplings for myo-inositol were optimized by simultaneous fitting of high-quality spectra.

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