Abstract #2013

The effect of basis sets on the analysis of in vivo brain MRS data obtained with standard PRESS sequences

Martin Gajdošík¹, Karl Landheer¹, Kelley M. Swanberg¹, Lawrence S. Kegeles^2,3,4, Dikoma C. Shungu⁵, Camilo de la Fuente-Sandoval^6,7, and Christoph Juchem^1,4

¹Department of Biomedical Engineering, Columbia University, New York City, NY, United States, ²Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York City, NY, United States, ³New York State Psychiatric Institute, New York City, NY, United States, ⁴Department of Radiology, Columbia University Medical Center, New York City, NY, United States, ⁵Weill Cornell Medicine, New York City, NY, United States, ⁶Laboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico, ⁷Department of Neuropsychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico

Point resolved spectroscopy sequence (PRESS) is the most commonly used sequence for in vivo magnetic resonance spectroscopy. While implemented by all major vendors, implementation details like timings, durations and shapes of the RF pulses differ among them. Here, we investigate the impact that inappropriate basis information can have on MRS metabolite quantification with linear combination modeling for quantification.

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