Aberrations of hippocampal subfields and microstructure are well studied, however, current in-vivo measures of microstructure are non-specific towards intra-hippocampal pathways and neurites within subfields. This is partly due to its complex and folded structure. Although highly folded, the hippocampus maintains an intrinsic coordinate system with well defined axes along the anterior-posterior, proximal-distal, and inner-outer dimensions. Importantly, hippocampal microstructure tends to align with these axes. Specific macrostructural measures such as gradient vector fields can be derived from these axes. Leveraging these measures, we were able to find systematic correlations between macrostructure and local microstructure in the hippocampus.
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