Abstract #2040

Microstructural Diffusion MRI in Mouse Models of Severe and Repetitive Mild Traumatic Brain Injury

Naila Rahman^1,2, Kathy Xu², Nico Arezza^1,2, Kevin Borsos^1,2, Matthew Budde³, Arthur Brown^2,4, and Corey Baron^1,2

¹Medical Biophysics, Western University, London, ON, Canada, ²Robarts Research Institute, London, ON, Canada, ³Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, ⁴Anatomy and Cell Biology, Western University, London, ON, Canada

Microstructural diffusion MRI (dMRI) improves the specificity required to detect microstructure changes related to pathophysiology. Oscillating gradient spin-echo (OGSE) dMRI is sensitive to structural disorder and microscopic anisotropy (µA) dMRI is sensitive to water diffusion anisotropy independent of neuron fiber orientation. In this work, OGSE and µA protocols were implemented to enable in vivo longitudinal scanning at 9.4T. Preliminary data in a rodent model of traumatic brain injury (TBI) revealed changes in mean diffusivity dependence on OGSE frequency post-TBI and changes in spherical tensor kurtosis (sensitive to cell size heterogeneity), compared to healthy mice.

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