Meeting Banner
Abstract #2040

Microstructural Diffusion MRI in Mouse Models of Severe and Repetitive Mild Traumatic Brain Injury

Naila Rahman1,2, Kathy Xu2, Nico Arezza1,2, Kevin Borsos1,2, Matthew Budde3, Arthur Brown2,4, and Corey Baron1,2
1Medical Biophysics, Western University, London, ON, Canada, 2Robarts Research Institute, London, ON, Canada, 3Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, 4Anatomy and Cell Biology, Western University, London, ON, Canada

Microstructural diffusion MRI (dMRI) improves the specificity required to detect microstructure changes related to pathophysiology. Oscillating gradient spin-echo (OGSE) dMRI is sensitive to structural disorder and microscopic anisotropy (µA) dMRI is sensitive to water diffusion anisotropy independent of neuron fiber orientation. In this work, OGSE and µA protocols were implemented to enable in vivo longitudinal scanning at 9.4T. Preliminary data in a rodent model of traumatic brain injury (TBI) revealed changes in mean diffusivity dependence on OGSE frequency post-TBI and changes in spherical tensor kurtosis (sensitive to cell size heterogeneity), compared to healthy mice.

This abstract and the presentation materials are available to members only; a login is required.

Join Here