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Abstract #2041

Susceptibility-induced fiber orientation dependency of the DWI signal in white matter measured in ex vivo rat brain at 7 T

Sidsel Winther1,2, Mariam Andersson1,2, Henrik Lundell2, and Tim Dyrby1,2
1DTU Compute, Technical University of Denmark, Kongens Lyngby, Denmark, 2Danish Research Center for Magnetic Resonance, Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark

Magnetic susceptibility of myelin induces morphology- and orientation-dependent perturbations of the B_0-field. At the microstructural scale of brain white matter, the main contribution to these perturbations comes from myelin. Here, we show that a consequence of this is a fiber-orientation-dependent bias of the DWI-signal across white matter regions in an ex vivo rat brain. This implies that biophysical modeling must regard susceptibility at the microstructural scale in order not to become biased as well. Higher field strength will increase the bias and vice versa. Hence, especially pre-clinical scans are affected.

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