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Abstract #2043

Cognitive training-derived microstructural and functional neuroplasticity and the neural mechanisms underlying the far-transfer effect

Daisuke Sawamura1,2, Ryusuke Suzuki3, Shinya Sakai1, Keita Ogawa4, Xinnan Li2, Hiroyuki Hamaguchi2, and Khin Khin Tha5
1Department of Rehabilitation Science, Hokkaido University, Sapporo, Japan, 2Department of Biomarker Imaging Science, Hokkaido University, Sapporo, Japan, 3Department of Medical Physics, Hokkaido University Hospital, Sapporo, Japan, 4Department of Rehabilitation, Hokkaido University Hospital, Sapporo, Japan, 5Global Center for Biomedical Science and Engineering, Hokkaido University Faculty of Medicine, Sapporo, Japan

Little is known about how microstructural and functional neuroplasticity occurs upon cognitive training and the relationship between cognitive training-derived brain changes and cognitive performance. This prospective study aimed to elucidate cognitive training-derived neuroplasticity and the mechanism underlying transfer effects using diffusion spectrum imaging (DSI) and resting-state functional MRI (rsfMRI). The results suggest that the right inferior parietal lobule and its neural connections and the right cerebellar vermis may modulate the far-transfer effect.

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