Abstract #2043

Cognitive training-derived microstructural and functional neuroplasticity and the neural mechanisms underlying the far-transfer effect

Daisuke Sawamura^1,2, Ryusuke Suzuki³, Shinya Sakai¹, Keita Ogawa⁴, Xinnan Li², Hiroyuki Hamaguchi², and Khin Khin Tha⁵

¹Department of Rehabilitation Science, Hokkaido University, Sapporo, Japan, ²Department of Biomarker Imaging Science, Hokkaido University, Sapporo, Japan, ³Department of Medical Physics, Hokkaido University Hospital, Sapporo, Japan, ⁴Department of Rehabilitation, Hokkaido University Hospital, Sapporo, Japan, ⁵Global Center for Biomedical Science and Engineering, Hokkaido University Faculty of Medicine, Sapporo, Japan

Little is known about how microstructural and functional neuroplasticity occurs upon cognitive training and the relationship between cognitive training-derived brain changes and cognitive performance. This prospective study aimed to elucidate cognitive training-derived neuroplasticity and the mechanism underlying transfer effects using diffusion spectrum imaging (DSI) and resting-state functional MRI (rsfMRI). The results suggest that the right inferior parietal lobule and its neural connections and the right cerebellar vermis may modulate the far-transfer effect.

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