We use model-based diffusion MRI to assess microstructural changes associated with short-term plasticity. Neuroplasticity changes are the foundation of experience. These mechanisms include microstructural rearrangements which can manifest even after short learning episodes. DTI has proven effective in highlighting such changes. However, the connection with the underlying microstructural processes remains speculative. Biophysical modelling can help interpreting such changes. We use NODDI and CHARMED models to examine MD changes obtained in a spatial navigation task. NODDI’s FWF and CHARMED’s hMD share similar cortical patterns of decrease as MD. FWF exhibited higher sensitivity than MD and hMD to capture microstructural changes.