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Abstract #2045

White matter microstructure associated with functional connectivity changes following short-term learning of a visuomotor sequence

Stefanie A. Tremblay1,2, Anna-Thekla J├Ąger3, Julia Huck1, Chiara Giacosa1, Stephanie Beram1, Uta Schneider3, Sophia Grahl3, Arno Villringer3,4,5,6, Christine Lucas Tardif7,8, Pierre-Louis Bazin3,9, Christopher J Steele3,10, and Claudine J. Gauthier1,2
1Physics, Concordia University, Montreal, QC, Canada, 2Montreal Heart Institute, Montreal, QC, Canada, 3Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4Clinic for Cognitive Neurology, Leipzig, Germany, 5Leipzig University Medical Centre, IFB Adiposity Diseases, Leipzig, Germany, 6Collaborative Research Centre 1052-A5, University of Leipzig, Leipzig, Germany, 7Biomedical Engineering, McGill University, Montreal, QC, Canada, 8Montreal Neurological Institute, Montreal, QC, Canada, 9Faculty of Social and Behavioral Sciences, University of Amsterdam, Amsterdam, Netherlands, 10Psychology, Concordia University, Montreal, QC, Canada

To characterize the temporal dynamics of plasticity, we conducted a longitudinal MRI study at ultra-high field (7T) during the learning process of a sequential visuomotor task, in a learning and control group. WM microstructure was altered in the tracts underlying the primary motor and sensorimotor cortices, and in tracts adjacent to the right supplementary motor area (SMA), where changes in functional connectivity were also found in this cohort. Our study provides evidence for short-term white matter plasticity in the sensorimotor network, where the SMA would play a key role in linking the spatial and motor aspects of motor sequence learning.

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