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Abstract #2046

Tissue Microstructural Changes following Four-Week Neurocognitive Training: Observations of Double Diffusion Encoding MRI

Xinnan Li1, Daisuke Sawamura2, Hiroyuki Hamaguchi1, Yuta Urushibata3, Thorsten Feiweier4, Keita Ogawa5, and Khin Khin Tha1,6
1Department of Biomarker Imaging Science, Graduate School of Biomedical Science and Engineering, Hokkaido University, Sapporo, Japan, 2Department of Functioning and Disability, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan, 3Siemens Healthcare K.K., Tokyo, Japan, 4Siemens Healthcare GmbH, Erlangen, Germany, 5Department of Rehabilitation, Hokkaido University Hospital, Sapporo, Japan, 6Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan

A four-week neurocognitive training of spatial attention and working memory was conducted in 21 volunteers. A change in tissue microstructure was tested by using double diffusion encoding MRI, which revealed a decrease in ╬╝FA in the left middle frontal gyrus. This decrease showed a significant negative correlation with the changes in the response time as assessed by the orienting attention network test.

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