Abstract #2046

Tissue Microstructural Changes following Four-Week Neurocognitive Training: Observations of Double Diffusion Encoding MRI

Xinnan Li¹, Daisuke Sawamura², Hiroyuki Hamaguchi¹, Yuta Urushibata³, Thorsten Feiweier⁴, Keita Ogawa⁵, and Khin Khin Tha^1,6

¹Department of Biomarker Imaging Science, Graduate School of Biomedical Science and Engineering, Hokkaido University, Sapporo, Japan, ²Department of Functioning and Disability, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan, ³Siemens Healthcare K.K., Tokyo, Japan, ⁴Siemens Healthcare GmbH, Erlangen, Germany, ⁵Department of Rehabilitation, Hokkaido University Hospital, Sapporo, Japan, ⁶Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan

A four-week neurocognitive training of spatial attention and working memory was conducted in 21 volunteers. A change in tissue microstructure was tested by using double diffusion encoding MRI, which revealed a decrease in μFA in the left middle frontal gyrus. This decrease showed a significant negative correlation with the changes in the response time as assessed by the orienting attention network test.

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