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Abstract #2047

Microstructural alterations in the white matter of children with dyslexia assessed by multi-fascicle diffusion compartment imaging

Nicolas Delinte1, Claire Gosse2,3, Laurence Dricot3, Quentin Dessain1, Mathieu Simon1, Benoit Macq1, Marie Van Reybroeck2,3, and Gaetan Rensonnet1
1ICTEAM, UCLouvain, Louvain-la-Neuve, Belgium, 2IPSY, UCLouvain, Louvain-la-Neuve, Belgium, 3IoNS, UCLouvain, Brussels, Belgium

Dyslexia is a deviant development of both reading and spelling abilities affecting 5-12 % of children, yet the microstructural changes it induces in the white matter (WM) remain incompletely understood. This study analyzed multi-shell diffusion MRI on a population of 17 dyslexic children and 18 controls. Advanced models (Diamond & Microstructure Fingerprinting), able to separately characterize intersecting fascicles within a voxel, obtained stronger correlations with children's reading and spelling performances than traditional DTI and showed increased sensitivity. The novel indices, obtained from these models, suggested refined interpretations of the microstructural characteristics of dyslexia in WM pathways.

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