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Abstract #2050

Characterizing axonal and myelin microstructure development across early childhood using NODDI and qihMT

Jess E Reynolds1,2, Emma Tarasoff3, R Marc Lebel1,4, Bryce L Geeraert1, and Catherine Lebel1
1Department of Radiology, University of Calgary, Calgary, AB, Canada, 2Telethon Kids Institute, The University of Western Australia, Perth, Australia, 3Department of Neuroscience, University of Calgary, Calgary, AB, Canada, 4GE Healthcare, Calgary, AB, Canada

There is a need to better understand white matter development across early childhood, as it is a time of rapid brain development that supports ongoing cognitive and behavioral maturation. Here, we aimed to apply NODDI and qihMT techniques longitudinally to provide a more specific understanding of early brain development. Consistent with diffusion MRI research, these advanced diffusion and non-diffusion methods indicated earlier development of central tracts compared to more peripheral regions. NODDI and qiHMT metrics demonstrate that white matter development during early childhood is dominated by increasing axon density, alongside ongoing myelination and slightly decreasing axon coherence.

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