Abstract #2051

Investigating cortical microstructure in preterm-born adolescents using three-tissue compositional analysis

Thijs Dhollander¹, Claire Kelly^1,2, Ian Harding^3,4, Wasim Khan³, Richard Beare¹, Jeanie Cheong^2,5,6, Lex Doyle^2,5,6,7, Marc Seal^1,7, Deanne Thompson^1,2,7, and Peter Anderson^2,8

¹Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, ²Victorian Infant Brain Studies (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia, ³Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia, ⁴Monash Biomedical Imaging, Monash University, Melbourne, Australia, ⁵Newborn Research, The Royal Women's Hospital, Melbourne, Australia, ⁶Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, ⁷Department of Paediatrics, The University of Melbourne, Melbourne, Australia, ⁸Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, Australia

While many studies have used diffusion MRI to investigate white matter microstructure, fewer studies have investigated cortical grey matter microstructure. We investigated cortical microstructural tissue and fluid composition using diffusion tissue signal fractions from Single-Shell 3-Tissue Constrained Spherical Deconvolution, in a cohort of preterm-born children at 13 years of age (n=130). Compared with term-born controls (n=45), we identified several cortical regions exhibiting a relative shift from a grey matter-like composition towards a more fluid-like composition, potentially reflecting reduced cell density and increased free-water content. This illustrates the utility of 3-tissue compositional analysis for studying cortical microstructure in neurodevelopment.

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