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Abstract #2051

Investigating cortical microstructure in preterm-born adolescents using three-tissue compositional analysis

Thijs Dhollander1, Claire Kelly1,2, Ian Harding3,4, Wasim Khan3, Richard Beare1, Jeanie Cheong2,5,6, Lex Doyle2,5,6,7, Marc Seal1,7, Deanne Thompson1,2,7, and Peter Anderson2,8
1Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, 2Victorian Infant Brain Studies (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia, 3Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Australia, 4Monash Biomedical Imaging, Monash University, Melbourne, Australia, 5Newborn Research, The Royal Women's Hospital, Melbourne, Australia, 6Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, 7Department of Paediatrics, The University of Melbourne, Melbourne, Australia, 8Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, Australia

While many studies have used diffusion MRI to investigate white matter microstructure, fewer studies have investigated cortical grey matter microstructure. We investigated cortical microstructural tissue and fluid composition using diffusion tissue signal fractions from Single-Shell 3-Tissue Constrained Spherical Deconvolution, in a cohort of preterm-born children at 13 years of age (n=130). Compared with term-born controls (n=45), we identified several cortical regions exhibiting a relative shift from a grey matter-like composition towards a more fluid-like composition, potentially reflecting reduced cell density and increased free-water content. This illustrates the utility of 3-tissue compositional analysis for studying cortical microstructure in neurodevelopment.

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