Understanding how the brain develops during adolescence is important for evaluating neuronal developments that affect mental health throughout the lifespan. This study uses 3-tissue constrained spherical deconvolution (3T-CSD) to examine the relationship between brain diffusion microstructure in deep white matter ROIs and pubertal development in a cross-sectional group of 4752 adolescents. An anisotropic diffusion signal fraction was found to have a negative correlation, while an intracellular isotropic diffusion signal fraction had a positive correlation with pubertal development across the majority of axonal ROIs. These results provide evidence for complex microstructural changes in brain development within the white matter skeleton.
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