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Abstract #2054

Characterizing Temporal Pole Microstructure with Diffusion Kurtosis Imaging in Temporal Lobe Epilepsy

Loxlan Wesley Kasa1,2, Terry Peters1,2,3,4, Seyed M Mirsattari3,4,5, Ali R Khan1,2,3, and Roy AM Haast1
1Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada, 2School of Biomedical Engineering, Western University, London, ON, Canada, 3Department of Medical Biophysics, Western University, London, ON, Canada, 4Department of Medical Imaging, Western University, London, ON, Canada, 5Department of CNS, Western University, London, ON, Canada

The role of the temporal pole (TP) in nonlesional temporal lobe epilepsy (‘MRI-’) has been underappreciated. Better understanding of the possible white matter (WM) microstructural changes within the TP in MRI- is important for informing resective surgery. The purpose of this study was to evaluate the use of diffusion kurtosis imaging (DKI), to detect abnormalities at specific regions along WM fibre bundles proximal to the TP in MRI- and lesional TLE (‘MRI+’). DKI was able to detect possible microstructural changes near TP in both MRI+ and MRI- subjects not clearly visible using diffusion tensor imaging metrics.

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