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Abstract #2055

Assessment of Perivascular Glymphatic System Activity in Middle-aged HIV Infected Patients on Combination Antiretroviral Therapies

Benedictor Alexander Nguchu1, Jing Zhao 2,3, Yanming Wang1, Jean de Dieu Uwisengeyimana1, Xiaoxiao Wang1, Bensheng Qiu1, and Hongjun Li2,3
1Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, China, 2Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, China, 3School of Biological Science and Medical Engineering, Beihang University, Beijing, China

The brain activity underlying cognitive processing can be affected by HIV. We examine the ALPS index, a measure reflecting glymphatic system activity, along the perivascular space and its relationship with cognitive performance in middle-aged HIV infected patients successfully adhering to antiretroviral therapy. We found that the ALPS index was increased significantly in middle-aged HIV-infected patients receiving cART and was correlated with attention and working memory. The duration on cART was also associated with some cognitive measures. These findings suggest that ALPS index might provide an impetus for understanding cognitively relevant diffusivity changes following HIV or long-term use of cART.

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