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Abstract #2056

Altered Functional Connection and Neuroinflammation in Fibromyalgia Using Independent Component Analysis and Diffusion Kurtosis MRI

JIA-WEI Liang1, Tang-Jun Li2, Yao-Wen Liang3, Ting-Chun Lin3, Yi-Chen Lin3, Jiunn-Horng Kang2,4, You-Yin Chen3,5, and Yu-Chun Lo5
1Department of Biomedical Optoelectronic, Taipei Medical University, Taipei, Taiwan, 2College of Medicine, Taipei Medical University, Taipei, Taiwan, 3Department of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan, 4Department of Physical Medicine & Rehabilitation, Taipei Medical University, Taipei, Taiwan, 5Ph.D. Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan

Recently, neuroinflammation was proposed as an important role in fibromyalgia. However, the correlation between neuroinflammation and functional connection in fibromyalgia patients remained unclear. Fibromyalgia patients and healthy control participants were recruited to investigate the mechanism of fibromyalgia. Independent component analysis, diffusion kurtosis MRI and cortical thickness estimation were applied in this study. The finding implied that neuroinflammation and structural change of brain were associated with the abnormal functional connection in fibromyalgia.

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