Abstract #2056

Altered Functional Connection and Neuroinflammation in Fibromyalgia Using Independent Component Analysis and Diffusion Kurtosis MRI

JIA-WEI Liang¹, Tang-Jun Li², Yao-Wen Liang³, Ting-Chun Lin³, Yi-Chen Lin³, Jiunn-Horng Kang^2,4, You-Yin Chen^3,5, and Yu-Chun Lo⁵

¹Department of Biomedical Optoelectronic, Taipei Medical University, Taipei, Taiwan, ²College of Medicine, Taipei Medical University, Taipei, Taiwan, ³Department of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan, ⁴Department of Physical Medicine & Rehabilitation, Taipei Medical University, Taipei, Taiwan, ⁵Ph.D. Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan

Recently, neuroinflammation was proposed as an important role in fibromyalgia. However, the correlation between neuroinflammation and functional connection in fibromyalgia patients remained unclear. Fibromyalgia patients and healthy control participants were recruited to investigate the mechanism of fibromyalgia. Independent component analysis, diffusion kurtosis MRI and cortical thickness estimation were applied in this study. The finding implied that neuroinflammation and structural change of brain were associated with the abnormal functional connection in fibromyalgia.

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